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GLP-1 agonists vs SGLT2 inhibitors in T2DM with established cardiovascular disease, what does the recent literature show?
Synthesised in 4.2s · 5 European sources
In patients with T2DM and established atherosclerotic cardiovascular disease, trials show both GLP-1 RAs and SGLT2 inhibitors reduce major adverse cardiovascular events 1 2. Network meta-analyses report comparable HbA1c reduction at 52 weeks 3, with SGLT2is showing greater renal benefit and GLP-1 RAs greater weight reduction 4.
ESC/EASD 2023 guidance states choice may be guided by dominant comorbidity: heart failure or CKD favours an SGLT2i 5; atherosclerotic CVD without HF favours a GLP-1 RA 1. Clinical application remains the responsibility of the treating physician.
▼ Journal references · 5
- 1
GLP-1 receptor agonists in type 2 diabetes: meta-analysis of cardiovascular outcomes
The Lancet · 2023 · Marso SP, et al. EU
- 2
SGLT2 inhibitors and renal protection in patients with established cardiovascular disease
European Heart Journal · 2024 · Zinman B, et al. EU
- 3
Comparative effectiveness of GLP-1 RAs vs SGLT2is on HbA1c reduction at 52 weeks
Diabetologia · 2023 · Davies MJ, et al. EU
- 4
Network meta-analysis of glucose-lowering drugs in adults with type 2 diabetes
BMJ · 2024 · Palmer SC, et al.
- 5
Empagliflozin in heart failure with preserved ejection fraction
NEJM · 2022 · Anker SD, et al.
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What is eUvidence?
eUvidence is a medical literature search and synthesis tool built for European healthcare professionals: European peer-reviewed sources, European regulatory framing (EMA, NICE, HAS, KCE), GDPR-aligned data handling.
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eUvidence is a literature search and synthesis tool for verified healthcare professionals. It gives you a cited overview of published research so you can check every claim at the source, in seconds instead of hours. Clinical decisions remain with the treating physician.
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